IMCI Seminar: Mathematical Modeling of Coupled Cardiovascular-Ocular Hemodynamics

Washington State University, Department of Mathematics and Statistics
This presentation introduces Eye2Heart, an integrated mathematical framework linking
cardiovascular and ocular hemodynamics through a system of nonlinear ordinary differential
equations. The model, verified with experimental and clinical datasets, successfully
reproduces both systemic and ocular physiological markers. Computational experiments
indicate that increased intraocular pressure primarily reduces ocular perfusion, whereas
diminished left ventricular compliance leads to decreased cardiac output and retinal blood
flow. When both factors coexist, venous circulation is further compromised, offering
mechanistic insight into disorders such as normal-tension glaucoma. By quantitatively
bridging the eye and heart, Eye2Heart establishes a foundation for oculomics that
complements AI-driven image analysis and advances physiologically informed approaches to
precision medicine.