Brown Bag Lunch Series: Fighting fire with fire: using a mild virus to prevent lethal virus infection in the respiratory tract

Session led by Tanya Miura

Our initial project on the CMCI COBRE award was designed to identify parameters that determine disease outcomes during respiratory viral coinfection in a mouse model. Through this work we identified multiple virus pairs that resulted in reduced disease severity upon coinfection, which depends upon the viral doses and order of coinfecting viruses. For example, rhinovirus prevents mortality of a subsequent influenza virus infection when delivered two days before lethal influenza virus. Our current work is aimed at identifying immunological mechanisms required for this protection. This discussion will focus on disease severity, virology, and immunology data that will be used for mechanistic modeling of viral coinfection.

Come join us as Tanya Miura presents on this topic this Monday!