Project Team: James T. Van Leuven, Emma Altman The microbial communities colonizing animal guts are highly influential to host health and development. Animal hosts are impacted by the species of microbes present and temporal changes in their abundances, but the forces governing these dynamics are poorly understood. Bacteriophages modulate bacterial community composition through predation. They…
For future reference or if you weren’t able to attend the Brown Bag Lunch yesterday, here are the slides presented by IMCI Director Holly Wichman regarding our Pilot Grant program. Please remember, you are welcome to reach out to the leadership team directly and at any time if you have questions about whether your research…
Project Team: Jagdish Patel, Deborah Stenkamp, Dharmesh Patel, Jonathan Barnes Note: This pilot grant evolved out of the research produced by the working group, Evolution of Tandemly-Replicated Opsin Genes: Molecular Models that Predict Spectral Shifts. Vision is one of the most sophisticated biochemical system in humans and serves as a primary environmental input. In other organisms,…
The University Awards for Excellence recognize and encourage excellence in all forms at the academic level. Recently, the 2019 Interdisciplinary Award was presented to the Flow Ventilators Team for their collaborative efforts for working to improve treatments for asthma and other lung diseases. Team members include 4 researchers from 2 colleges: Tao Xing, associate professor…
Project Team: Matthew Bernards, Nathan Schiele, Dharmeshkumar Patel, Stephanie Haag In the US, over 130,000 surgical procedures each year require a bone graft material, but almost 30% of grafts fail. Recent studies have implicated albumin as important during bone repair and it has been adapted for improving scaffold integration with bone tissue. This is important…
Project Team: Audrey Fu, Md. Bahadur Badsha, Evan Martin Complex diseases often involve changes in DNA sequence, and in DNA transcription and methylation, an epigenetic process that can both regulate and be regulated by gene expression. These changes result in a wide range of symptoms or multiple subtypes of the same disease. In breast cancer,…
Project Team: Alan Kolok, Lucas Sheneman, Chantal Vella The long-term goal of this program is to model the associations that occur among metal contamination (as a consequence of mining), watershed geography and adverse human health impacts across the Rocky Mountains. In this pilot project, we will focus on generating a predictive classifier model that includes…
Project Team: Aleksandar Vakanski, Stephen Lee, David Paul, Russell Baker, Hyung-Pil Jun The long-term goal of this project is to develop a commercial system for evaluation of physical therapy and rehabilitation exercises performed by patients in a home-based setting. The system will employ a machine learning approach for evaluation of patient movements, based on input…
Project Team: Christopher Marx (PI), Andreas Vasdekis (Co-PI), Chris Remien, Siavash Riazi, Denis Liyu Multidrug antibiotic persistence, which allows some cells that lack genetic resistance to survive antibiotic stresses by becoming dormant, is a major public health concern. This exploratory project will use data from state-of-the-art image cytometry and single-cell analysis in combination with mechanistic mathematical…
Project Team: Tao Xing (PI), Gordon Murdoch (Co-PI), Michelle Wiest, Loel Fenwick, Rabijit Dutta Without adequate respiration, life ceases in as little as three minutes. The failure of effective spontaneous respiration requires immediate intervention to preserve life. However, lungs are far more complicated than simple bags at the ends of tubes. Life support or therapeutic…