Project Director: Tanya Miura Project Team: Craig Miller, Onesmo Balemba, Jake Ferguson, Jagdish Patel, JT Van Leuven, Andres Gonzalez Viral infections in the lower respiratory tract cause severe disease and are responsible for a majority of pediatric hospitalizations, approximately 20% of which are infected by more than one viral pathogen. Clinical data indicate that disease severity…
Project Team: Marty Ytreberg (PI), Celeste Brown (Co-PI), Craig Miller (Co-PI), Holly Wichman, Tanya Miura, Chris Mirabzadeh, Kyle Martin Ebola surface glycoprotein (blue) bound by antibodies (brown). In dark blue are other known epitopes (antibody binding sites). In orange and red are mutations from the recent epidemic in West Africa. The goal of this project,…
Project Team: Christopher Marx (PI), Andreas Vasdekis (Co-PI), Chris Remien, Siavash Riazi, Denis Liyu Multidrug antibiotic persistence, which allows some cells that lack genetic resistance to survive antibiotic stresses by becoming dormant, is a major public health concern. This exploratory project will use data from state-of-the-art image cytometry and single-cell analysis in combination with mechanistic mathematical…
Project Team: Scott Grieshaber (PI), Nicole Grieshaber, Anders Omsland, Christopher Remien Chlamydia are obligate intracellular bacteria that cause a range of diseases in both man an animals. Chlamydia like bacteria infect just about all eukaryotic organisms on the planet, from man to amoeba. All Chlamydiae, including the human pathogens C. trachomatis, C. pneumoniae, and C. psittaci, share a…
Project Team: Tao Xing (PI), Gordon Murdoch (Co-PI), Michelle Wiest, Loel Fenwick, Rabijit Dutta Without adequate respiration, life ceases in as little as three minutes. The failure of effective spontaneous respiration requires immediate intervention to preserve life. However, lungs are far more complicated than simple bags at the ends of tubes. Life support or therapeutic…
Working Group leader: Marty Ytreberg Group members: Craig Miller, Tanya Miura, Paul Rowley, Holly Wichman, Brenda Rubenstein, Jagdish Patel, JT Van Leuven, Ticak Tomislav, Angela Crabtree, LuAnn Scott, Kevin Hutchison, Yesol Sapozhnikov, Jonathan Barnes, Laura Steiner, Sierra Beach, Shunji Li, Peik Lund, Hersh Gupta, Erin Skeens, Gabriel Monteiro da Silva, Jordan Yang, Mohamed Megheib Originated:…