Working Group Leader: Marty Ytreberg Group Members: Jonathan Barnes, Jagdish Patel, America Chi Originated: December 15, 2022 Description: MoMo will brainstorm ideas to participate in the pandemic preparedness proposal that will be led by University of Texas, Austin.
Title: Using molecular modeling to assess structural conservation of KP4-Like proteins and their potential as antifungals Project Team: Paul Rowley, Jonathan Barnes Start Date: May 2022 KP4 protein has been used as a potent antifungal drug to reduce the spoilage of commodity crops. While the potential of KP4 has not been fully realized due to…
Title: Synergistic mutations allow for antibody resistance in respiratory syncytial virus Project Team: Tanya Miura, Jonathan Barnes Start Date: June 2022 This project was initially funded by the NSF EPSCoR Track II Geno-Pheno Grant to use molecular modeling to predict antibody escape variants of respiratory syncytial virus (RSV). In that work, we identified five novel…
Title: The modeling of the HIV Capsid with novel binding sites on Nucleoporin 153 Project Team: Paul Rowley, Shunji Li, Jagdish Patel Start Date: August 2021 A molecular modeling approach will be used to assess whether homologs of NUP153 motif-1 interact with the HIV-1 capsid. We have preliminary binding data which suggest at least one…
Title: Myofilament Cooperative Activation in Human and Porcine Myocardium Project Team: Daniel Fitzsimons, Tuan Phan Start Date: September 2021 Contraction and relaxation of the mammalian heart is a cooperative process involving the binding of Ca2+ and myosin cross-bridges to the thin filament. While the cooperative effects of Ca2+ and myosin cross-bridge binding to the thin…
Title: Optimizing spatiotemporal modeling for public health risk analysis Project Team: Helen Brown, Christopher Murphy, Chris Williams, Erich Seamon, Mohamed Megheib Start Date: September 2021 This is a continuation of small area estimate (SAE) modeling of Idaho Behavioral Risk Factor Surveillance System (BRFSS) health indicators. In 2019 the Pl sought MAG support to model obesity…
“The hidden half: How interactions between plants and microbes belowground drive ecosystem responses to global change” Accurate projections of the future land carbon sink by global climate models depend on how they represent nutrient constraints on primary production. While empirical research has highlighted the rhizosphere (i.e., the area immediately surrounding roots) as a hotspot for…
U of I Department of Biology Professor Chris Marx has been awarded a $1.4 million grant from the Department of Energy to support his project “Converting methoxy groups on lignin-derived aromatics from a toxic hurdle to a useful resource: a systems-driven approach”. This project involves the Marx and Vasdekis labs here at University of Idaho, as…
IMCI invites applications for two of our initiatives. Both initiatives support research that involves modeling from any field. Also note that we are hosting a Brown Bag Lunch discussion of DAGs specifically for researchers from CLASS and other colleges that may be unaware of the opportunities we offer – see details below. Anyone who wants…
IMCI invites applications for two of our initiatives. Both initiatives support research that involves modeling from any field. Also note that we are hosting a Brown Bag Lunch discussion of DAGs specifically for researchers from CLASS and other colleges that may be unaware of the opportunities we offer – see details below. Anyone who wants…