Project Team: Paul Rowley (PI), Jagdish Patel
Start Date: April 1, 2018
This Modeling Access Grant (MAG) is to:
Title: The modeling of the HIV Capsid with novel binding sites on Nucleoporin 153 Project Team: Paul Rowley, Shunji Li, Jagdish Patel Start Date: August 2021 A molecular modeling approach will be used to assess whether homologs of NUP153 motif-1 interact with the HIV-1 capsid. We have preliminary binding data which suggest at least one…
This article was published by the Office of Research and Economic Development in the October 2019 Scholars and Researchers newsletter. IMCI supports Zebrafish research through modeling via the Evolution of Tandemly-Replicated Opsin Genes: Molecular Models That Predict Spectral Shifts (which led to an article featured on the cover of Science magazine) and Bioinformatic Analysis of…
Project Team: Deborah Stenkamp (PI), Diana Mitchell, Robert Mackin, Jagdish Patel Gene replication is an established mechanism for the generation of raw genetic material upon which evolution may act. For example, tandem replication of genes to generate arrays of paralogs underlies functional diversification in vertebrate sensory systems. Tandem replication of opsin (visual pigment) genes and subsequent neofunctionalization provide…
Project Team: Helen Brown (PI), Christopher Murphy, Chantal Vella, Marco Mesa-Frias, Michelle Wiest This project will aim to develop or adapt an existing model to generate small area estimates in Idaho counties of the factors that place individuals at highest risk for obesity (e.g. sedentary behaviors, food insecurity, sugar-sweetened beverage consumption). Knowledge of the local…
Title: DNA and protein modeling for P/asmodium falciparum dhfr and dhps sequences derived from an existing study in Kenya Project Team: Shirley Luckhart, Dharmesh Patel, JT Van Leuven Start Date: June, 2019 The UI, USUHS, and USAMRU-K teams have collected human blood samples from study-enrolled Kenyan adults for an NIH-funded project focused on defining the…
Title: Using molecular modeling to assess structural conservation of KP4-Like proteins and their potential as antifungals Project Team: Paul Rowley, Jonathan Barnes Start Date: May 2022 KP4 protein has been used as a potent antifungal drug to reduce the spoilage of commodity crops. While the potential of KP4 has not been fully realized due to…