The Rapid Evolution of Primate Haptoglobin and the Molecular Modeling of its Interaction with the Trypanosome Hemoglobin-Haptoglobin Receptor

Project Team: Paul Rowley, Jagdish Patel, Dharmesh Patel

Start Date: May 2019

Molecular dynamics simulations will help Principal Investigators Rowley and Jagdish Patel analyze FoldX. The team expects this research to lead to a publication and serve as the foundation for future grants to investigate haptoglobin evolution in other mammalian species that serve as reservoirs of trypanosomes.

Similar Posts

Drug-Target Interactions of 5HT2B Receptors and Its Inhibitors
|

Drug-Target Interactions of 5HT2B Receptors and Its Inhibitors

Project Team: Jakob Magolan (PI), Xiong Zhang, Jagdish Patel Depression is a common psychiatric disorder. According to the most prevalent monoamine theory, depression is caused by an imbalance of brain neurotransmitters: serotonin, noradrenaline, and dopamine. All currently available antidepressant drugs act mainly by increasing the concentration of these in the brain. Primary drawbacks of current…

Modeling Access Grants Announcement
|

Modeling Access Grants Announcement

Aniruddha Belsare, Ph. D. has recently joined the cohort of postdoctoral fellows in the CMCI Collaboratorium and is available to help with appropriate Modeling Access Grants (see below). Aniruddha is a disease modeler with a background in veterinary medicine, disease ecology, and conservation research. He uses an agent-based modeling approach to investigate complex host-pathogen systems….

Evolution of Tandemly-Replicated Opsin Genes: Molecular Models That Predict Spectral Shift
|

Evolution of Tandemly-Replicated Opsin Genes: Molecular Models That Predict Spectral Shift

Project Team: Deborah Stenkamp (PI), Diana Mitchell, Robert Mackin, Jagdish Patel Gene replication is an established mechanism for the generation of raw genetic material upon which evolution may act. For example, tandem replication of genes to generate arrays of paralogs underlies functional diversification in vertebrate sensory systems. Tandem replication of opsin (visual pigment) genes and subsequent neofunctionalization provide…

Mathematical Modeling of Nutritional Factors and Bacterial Communities of the Maternal-Infant Dyad
|

Mathematical Modeling of Nutritional Factors and Bacterial Communities of the Maternal-Infant Dyad

Project Director: Mark McGuire Project Team: Janet Williams, Sarah Brooker, Chris Remien, Ben Ridenhour, JT Van Leuven Myriad microbial communities within and on the human body interact constantly with each other and environmental factors, and although much work has focused on characterizing these various community structures (especially in adults), almost nothing is known about how…

Bioinformatic Analysis of Immune-Cell-Derived, Regeneration-Specific Transcripts in Zebrafish

Bioinformatic Analysis of Immune-Cell-Derived, Regeneration-Specific Transcripts in Zebrafish

Project Team: Diana Mitchell (PI), Ousseini Isaaka Start Date: August 1, 2018 For the 19 genes without significant similarity to genes in humans, the following analyses will be performed in order to identify their putative functions: identify conserved proteins or protein domains predict protein localization search for functional domains predict cellular and functional pathways synteny…

Tanya Miura Awarded Modeling Access Grant

Tanya Miura Awarded Modeling Access Grant

Title: Synergistic mutations allow for antibody resistance in respiratory syncytial virus Project Team: Tanya Miura, Jonathan Barnes Start Date: June 2022 This project was initially funded by the NSF EPSCoR Track II Geno-Pheno Grant to use molecular modeling to predict antibody escape variants of respiratory syncytial virus (RSV). In that work, we identified five novel…