Project PI: Jagdish Patel This research project is to identify the correct bound conformations of veranamine in signma-1 and 5HT2B receptors. Crystal coordinates of sigma-1 and 5HT2B receptors will be downloaded from the Protein Data Bank. Both of the receptor structures will then be used to perform ordinary molecular dynamics to sample various conformations available….
Working Group leader: Aniruddha Belsare Group members: Craig Miller, JT Van Leuven, Ryan Long, Katherine Lee Originated: September 2017 Description: Given the interconnectedness of animal health, environmental health and human health and well-being, it is necessary to investigate the ecological contexts of animal disease systems that have public health, conservation or economic implications. Such host-pathogen…
The NIH-funded Center for Modeling Complex Interactions (CMCI) at the University of Idaho is an intellectual, cultural, and physical environment that fosters synergy in interdisciplinary biomedical research. The focal point of CMCI is the Collaboratorium, a space and a culture for collaborative modeling. It brings together faculty and students from both the empirical and modeling…
Working Group leader: Tanya Miura Group members: Paul Rowley, Shunji Li, Angela Crabtree, Sierra Beach, Kevin Hutchinson, Laura Steiner, Jordan Richter, Mark Lee, Lance Fredericks Originated: August, 2017 Description: MoVIES is a group designed to bring together the two IMCI-affiliated eukaryotic virology labs at U of I to discuss empirical approaches to test computational predictions…
Reproducibility of research results across repeated studies is a defining feature of science. However, in the last few years scientists across several fields including (but not limited to) psychology, cancer biology, biochemical science, preclinical research, ecology, and evolution have been facing difficulty reproducing well-known results in their respective fields. This disconcerting trend has resulted in…
Project Team: Marty Ytreberg (PI), Craig Miller, Brandon Ogbunugafor (University of Vermont), Daniel Weinreich (Brown University) Understanding how genotypes map to organismal phenotypes is one of the great unsolved problems in modern biology. This research is built on the principle that the biophysical properties of proteins represent general, computationally-predictable intermediaries for mapping genotypes to phenotypes. The…
Working Group leader: Bryn Martin Group members: Gordon Murdoch, Nathan Schiele, Gabriel Potirniche, Bert Tanner, Martin Mortazavi, Sajid Suriya Originated: September 2017 Description: This group is focused on measurement and modeling with respect to TBI. In specific, we are carrying out an INBRE Pilot project research grant project entitled, “Investigating the Impact of Arachnoid Trabeculae…
Project Team: Aleksandar Vakanski, Stephen Lee, David Paul, Russell Baker, Hyung-Pil Jun The long-term goal of this project is to develop a commercial system for evaluation of physical therapy and rehabilitation exercises performed by patients in a home-based setting. The system will employ a machine learning approach for evaluation of patient movements, based on input…
Project Team: Jakob Magolan (PI), Xiong Zhang, Jagdish Patel Depression is a common psychiatric disorder. According to the most prevalent monoamine theory, depression is caused by an imbalance of brain neurotransmitters: serotonin, noradrenaline, and dopamine. All currently available antidepressant drugs act mainly by increasing the concentration of these in the brain. Primary drawbacks of current…