Skip to main content

Drug-Target Interactions of 5...

Project Team: Jakob Magolan (PI), Xiong Zhang, Jagdish Patel Depression is a common psychiatric disorder. According to the most prevalent monoamine theory, depression is caused by an imbalance of brain neurotransmitters: serotonin, noradrenaline, and dopamine. All currently available antidepressant drugs act mainly by increasing the concentration of these in the brain. Primary drawbacks of current […]

Small Area Estimation of Obes...

Project Team: Helen Brown (PI), Christopher Murphy, Chantal Vella, Marco Mesa-Frias, Michelle Wiest This project will aim to develop or adapt an existing model to generate small area estimates in Idaho counties of the factors that place individuals at highest risk for obesity (e.g. sedentary behaviors, food insecurity, sugar-sweetened beverage consumption). Knowledge of the local […]

Mathematical Modeling of Nutr...

Project Director: Mark McGuire Project Team: Janet Williams, Sarah Brooker, Chris Remien, Ben Ridenhour, JT Van Leuven Myriad microbial communities within and on the human body interact constantly with each other and environmental factors, and although much work has focused on characterizing these various community structures (especially in adults), almost nothing is known about how […]

Mathematical Modeling of Huma...

Project Team: Alex Vakanski (PI), Stephen Lee, Jake Ferguson The current methods in the literature for representing human motions are based on modeling the movements at a single level of abstraction, either at a low-level (i.e., trajectory level) of abstraction or at the high-level (i.e., symbolic level) of abstraction. The proposed project will exploit the latest advances in […]

Evolution of Tandemly-Replica...

Project Team: Deborah Stenkamp (PI), Diana Mitchell, Robert Mackin, Jagdish Patel Gene replication is an established mechanism for the generation of raw genetic material upon which evolution may act. For example, tandem replication of genes to generate arrays of paralogs underlies functional diversification in vertebrate sensory systems. Tandem replication of opsin (visual pigment) genes and subsequent neofunctionalization provide […]

The Effect of Genetic Variati...

Project Team: Paul Rowley (PI), Jagdish Patel The interaction of host proteins with lentiviruses and other retroviruses and retrotransposons represents a major research theme of the Rowley lab. The proposed work fits well with the mission of the NIH and is a field of study that has traditionally been well supported. Dr. Rowley is fully […]

Developing Statistical Models...

Project Team: Berna Devezer (PI), Erkan Buzbas, Gustavo Nardin Reproducibility of scientific findings has long been considered a pillar of science. However, in the last decade, many disciplines life sciences have failed to reproduce major research findings. This reproducibility crisis has triggered a shift to revise current research practices. Examples include how to make biomedical findings more reproducible […]