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New Fish Rack System Helps Ad...

New Fish Rack System Helps Advance U of I’s Biomedical Research

This article was published by the Office of Research and Economic Development in the October 2019 Scholars and Researchers newsletter. IMCI supports Zebrafish research through modeling via the Evolution of Tandemly-Replicated Opsin Genes: Molecular Models That Predict Spectral Shifts (which led to an article featured on the cover of Science magazine) and Bioinformatic Analysis of […]

Shirley Luckhart awarded Mode...

Title: DNA and protein modeling for P/asmodium falciparum dhfr and dhps sequences derived from an existing study in Kenya Project Team: Shirley Luckhart, Dharmesh Patel, JT Van Leuven Start Date: June, 2019 The UI, USUHS, and USAMRU-K teams have collected human blood samples from study-enrolled Kenyan adults for an NIH-funded project focused on defining the […]

The Rapid Evolution of Primat...

Project Team: Paul Rowley, Jagdish Patel, Dharmesh Patel Start Date: May 2019 Molecular dynamics simulations will help Principal Investigators Rowley and Jagdish Patel analyze FoldX. The team expects this research to lead to a publication and serve as the foundation for future grants to investigate haptoglobin evolution in other mammalian species that serve as reservoirs […]

Chemistry Faculty Awarded CMC...

Project Team: Kristopher Waynant, Darren Thompson, Tyler Siegford, Jacob Kennedy, Dharmesh Patel Start Date: February 1, 2019 In preparation for a grant proposal to the National Institute for Dental and Craniofacial Research, CMCI Postdoctoral Fellow Dharmesh Patel will be dedicating some of his time over the next few months to prepare models for Chemistry faculty […]

Development of an Agent-Based...

We have a new MAG! Project Team: Ryan Long (PI), Nicole Bilodeau, Aniruddha Belsare Start Date: October 1, 2018 The models developed during this MAG project will be used to develop a better understanding of pneumonia dynamics in bighorn sheep populations and guide further research questions. The long-term goal of our work is to support […]

Bioinformatic Analysis of Imm...

Project Team: Diana Mitchell (PI), Ousseini Isaaka Start Date: August 1, 2018 For the 19 genes without significant similarity to genes in humans, the following analyses will be performed in order to identify their putative functions: identify conserved proteins or protein domains predict protein localization search for functional domains predict cellular and functional pathways synteny […]

Understanding Persistence and...

Project Team: Craig Miller (PI), Aniruddha Belsare, JT Van Leuven Start Date: June 2018 Context Rabies kills an estimated 59,000 people every year. Most of these deaths are from the poorest sectors of society in low-­ and middle-­income countries, where dogs are the principal reservoir of rabies [1]. There are two ways to limit human […]

Using Homology Modeling and M...

Project Team: Paul Rowley (PI), Jagdish Patel Start Date: April 1, 2018 This Modeling Access Grant (MAG) is to: build homology models for four toxin sequences based upon the KP4 toxin (~150 amino acid residues) crystal structure, run one micro second long molecular dynamics simulations of four homology models and KP4 toxin, and analyze simulations.

Modeling Stem Cell Behavior f...

Project Directors: Kyle Harrington, Nathan Schiele Project Team: Leo Epstein, Sophia Theodossiou, Aniruddha Belsare Tendons are collagen-rich musculoskeletal tissues that transfer mechanical forces from muscle to bone to allow for normal human movements, such as locomotion. Unfortunately, tendon injuries are frequent, treatment options are limited, and the mechanical function of tendon rarely returns to pre-injury […]

Modeling Access Grants Announ...

Aniruddha Belsare, Ph. D. has recently joined the cohort of postdoctoral fellows in the CMCI Collaboratorium and is available to help with appropriate Modeling Access Grants (see below). Aniruddha is a disease modeler with a background in veterinary medicine, disease ecology, and conservation research. He uses an agent-based modeling approach to investigate complex host-pathogen systems. […]