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University of Idaho Receives Grant of Nearly $11M for Biomedical Research Modeling

MOSCOW, Idaho — Aug. 13, 2020 — The University of Idaho has secured a grant of nearly $11 million from the National Institutes of Health to support continued modeling for biomedical research at U of I’s Institute for Modeling Collaboration and Innovation (IMCI).

The funding comes as Phase 2 of a Centers of Biomedical Research Excellence (COBRE) grant received by the U of I in 2015. COBRE grants support the establishment and development of biomedical research through awards granted in three sequential phases.

During Phase 1, grant funds of $10.6 million helped U of I students, staff and faculty researchers from nearly every college incorporate modeling in their projects. Funds financed projects such as studying disease severity and transmission rates in hosts infected with multiple pathogens at the same time and the role of social influence and human perceptions of infection risk when making vaccine choices. Phase 1 money also supported major equipment purchases that help facilitate the production of quantitative data, sponsored 11 postdoctoral fellowships and assisted faculty acquire nearly $20 million for additional research in the state of Idaho.

IMCI is supporting several research projects related to COVID-19.

“We are proud of our Institute for Modeling Collaboration and Innovation researchers who make important contributions to the state of Idaho and our nation,” University of Idaho President Scott Green said. “This team was instrumental to guiding statewide decisions in the early days of the COVID-19 pandemic. This biomedical research grant that is focused on cancer and the human microbiome will enable this talented team to further advance those efforts, helping our leaders and medical community save lives and improve living conditions in our country.”

The Phase 2 COBRE funds will continue to bolster U of I interdisciplinary biomedical research with new research projects studying cancer genomics, cancer imaging and interpreting variation in the human microbiome. New projects will be added over the course of this five-year grant.

“This funding allows us to continue what we’ve started and is particularly important to the campus community as we elevate our research profile,” said Holly Wichman, distinguished professor, IMCI director and principal investigator on the grant. “IMCI is a team-based idea generator that encourages participation across disciplines and among people who might otherwise never connect. Such collaboration fosters big ideas, and big ideas solve big problems.”

Brainstorming is a focus of IMCI. The COBRE grant finances research projects for early career faculty and pilot grants to explore possible new research directions. Funding also supports IMCI’s Modeling Core, a unique service center of postdoctoral researchers that offers diverse skills in various modeling approaches to principal investigators and working groups. It also supports learning opportunities for the campus community through a seminar series, workshops and hands-on data management and analysis training.

“We think all researchers should use modeling,” Wichman said. “Modeling improves research at all stages – hypothesis formulation, experimental design, analysis and interpretation – and provides a unifying language by which exchange of ideas can highlight commonalities and uncover unforeseen connections between problems.”

Modeling is especially useful when it is not feasible to experimentally explore all solutions to a problem. IMCI modeling approaches include everything from using mathematical formulas to replicate and predict real-world behavior to simulating molecule interactions to building physical and computational models of 3D objects. This funding will allow IMCI to bring new modeling expertise to the U of I research community.

This project was funded to University of Idaho by National Institutes of Health/National Institute of General Medical Sciences under award 2P20GM104420-06.The total project funding is $10,999,565.00 of which 100.00% is the federal share.

U of I Researchers Improve Restraint Devices Used for Injection of Moth Larvae

A team from the College of Science wants to improve the restraint devices used during injections of the greater wax moth larvae, a common laboratory animal. Injecting laboratory animals can be dangerous for researchers due to accidental needlesticks containing pathogenic microorganisms. In PLOS ONE, the team published designs for two new devices that reduce the handling of the larvae, protect against accidental needlestick injuries and maintain a high rate of successful injections. The devices are being used in the Rowley lab to help develop novel antifungal drugs to fight invasive fungal disease.

U of I Researchers, Moscow to Build on COVID-19 Wastewater Testing and Analysis

This news release, published by central University Communications and Marketing, was written by Alexiss Turner in the College of Engineering. IMCI has research partners and participants in nearly all U of I colleges.

MOSCOW, Idaho — July 21, 2020 — Researchers at the University of Idaho have partnered with the City of Moscow to improve wastewater testing for the presence of SARS-CoV-2, the virus that causes COVID-19. The team hopes to develop an early warning system for spikes in local cases.

Testing wastewater for the presence of SARS-CoV-2 is being conducted in areas worldwide, and estimating cases within a community based on the concentration of viral RNA in wastewater samples is a science that is gaining ground.

“Our primary contribution would be toward a bit of an early warning test,” said Erik Coats, U of I civil and environmental engineering professor.

Test results with higher concentrations of the virus, especially in areas with low case numbers, could foretell of future spikes in diagnosed patients.

“We could help hospitals focus on clearing up beds, gathering more personal protective equipment and making sure people are well-rested in advance of a wave,” Coats said.

Coats is working with Research Scientist Cynthia Brinkman, Department of Biology Professor Eva Top and Research Support Scientist Thibault Stalder. Department of Mathematics Assistant Professor Benjamin Ridenhour will assist with sampling schemes, analysis and extrapolation of results.

Moscow participated in a subsidized testing program through Massachusetts-based startup Biobot Analytics. The city provided Biobot with 24-hour composite wastewater samples in May and July.

SARS-CoV-2 was not detected for the three tests in early May. Biobot estimated 190 cases of COVID-19 from a test later that month. Analysis of samples sent July 1 and July 13 indicated 1,400 and 1,800 cases respectively.

“It is important to note that the Biobot data provides estimates, not actual cases,” Moscow City Supervisor Gary Riedner said in a statement released from the city. “While we can’t rely on the accuracy of the case estimation, the thing that is certain is that we are seeing significantly increased concentrations of COVID-19 in our wastewater.”

U of I testing will start using the same sample submitted to Biobot on July 1. Samples from the City of Twin Falls also have been obtained for analysis, and Coats is reaching out to regional wastewater treatment plants that have also participated in testing.

By comparing test results from different sources, researchers can better confirm the accuracy of their method and learn more about how that could translate into estimated cases.

“We’re hoping to develop a baseline,” Moscow Water Reclamation Utility Manager Evan Timar said. “We’re trying to compare and contrast testing results from different sources to see where we’re at and relay that information. We’re still learning and using that information to be proactive about what’s going on and to do our part for the wellbeing of the community.”

The city will collect and provide samples to the U of I lab, where researchers will isolate the viral RNA within the sample, reverse transcribe it to DNA, and then quantify regions within this DNA that are specific to SARS-CoV-2. This process allows detection of the SARS-CoV-2 at low concentrations. The method is being validated and optimized.

“The importance is the increase we observed,” U of I Research Support Scientist Thibault Stalder said. “With more samples, we will see the trend. For now, the data mirrored with public health data will be a great complementary tool.”

Wastewater consists of suspended solids and water, and one of the biggest challenges is identifying where the virus is most present in the sample. Reports suggest all carriers of the disease, asymptomatic or not, shed the virus, although virus shedding may be more prominent upon a person’s early infection.

Research activities are funded through the Institute for Modeling Collaboration and Innovation, U of I’s Office of Research and Economic Development and through unrestricted funds to researchers. Support has included funds to purchase a new biosafety cabinet that was recently installed in Coats’s lab on the U of I campus. All testing will occur in one location approved by U of I’s Institutional Biosafety Committee for this work.

Why R0 Is Problematic for Predicting COVID-19 Spread

Dr. Benjamin Ridenhour, Assistant Professor in the Department of Mathematics and Statistical Science and IMCI modeler, recently made significant contributions to an article in The Scientist, a magazine for life science professionals:

In the meantime, epidemiologists are reckoning with the uncertainty around SARS-CoV-2’s biological parameters by assuming a range of values rather than fixed numbers, says University of Idaho epidemiologist Benjamin Ridenhour, who is helping state officials predict the spread of the virus. He’s placing confidence intervals around every biological parameter in his model. His R0 could be anywhere from around 1.3 to 4, he says. “That way, obviously the chances that anything you model is exactly correct are zero, but hopefully you can capture it in that range somewhere.”

Read the entire article, written by Katarina Zimmer, here.

All-Hands Virtual Poster Session

IMCI is hosting a virtual poster session as part of the GenoPheno All-Hands meeting for the EPSCoR Track-2 project on May 28-29. You are invited to participate.

We are asking each presenter to create a 1-minute YouTube video that briefly introduces your research. A link to these “elevator pitch” videos will be included with the list of posters, so participants can easily decide which poster presentations to attend.

Each participant will be assigned a time slot to present and given a specific Zoom meeting ID.

Complete the following form if you wish to participate.

GenoPheno Virtual Poster SIGN UP


Once you have determined a title, have a YouTube video and a .pdf or .pttx file, please come back to submit those poster details and be assigned a time slot and Zoom meeting ID.


GenoPheno Virtual Poster DETAILS