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Reproducibility Does Not Equal Truth

Reproducibility Does Not Equal Truth

The CMCI Reproducibility in Sciences working group, or SciRep for short, has been meeting since the fall of 2015. Today, their most recent publication, “Scientific discovery in a model-centric framework: Reproducibility, innovation, and epistemic diversity,” was published in PLOS ONE. Congratulations!

Fig 2. A transition of our process of scientific discovery for an epistemically diverse population with replicator. A scientist (Bo) is chosen uniformly randomly from the population (1). Given the global model, the set of proposal models and their probabilities (given in percentage points inside models) are determined. In this population with no replicator, Bo proposes only models formed by adding an interaction (2). The proposed model selected (3) and the data generated from the true model (4) are used with the model comparison statistic (SC or AIC) to update the global model (5).

The American Council on Science and Health also picked up the story with their article, “Reconsidering The ‘Replication Crisis’ In Science.”

The following article was written by Leigh Cooper, U of I Science and Content Writer.


U of I Study Finds Scientific Reproducibility Does Not Equate to Scientific Truth

MOSCOW, Idaho — May 15, 2019 — Reproducible scientific results are not always true and true scientific results are not always reproducible, according to a mathematical model produced by University of Idaho researchers. Their study, which simulates the search for that scientific truth, was published today, May 15, in the journal PLOS ONE.

Independent confirmation of scientific results — known as reproducibility — lends credibility to a researcher’s conclusion. But researchers have found the results of many well-known science experiments cannot be reproduced, an issue referred to as a “replication crisis.”


“Over the last decade, people have focused on trying to find remedies for the ‘replication crisis,’” said Berna Devezer, lead author of the study and U of I associate professor of marketing in the College of Business and Economics . “But proposals for remedies are being accepted and implemented too fast without solid justifications to support them. We need a better theoretical understanding of how science operates before we can provide reliable remedies for the right problems. Our model is a framework for studying science.”

Devezer and her colleagues investigated the relationship between reproducibility and the discovery of scientific truths by building a mathematical model that represents a scientific community working toward finding a scientific truth. In each simulation, the scientists are asked to identify the shape of a specific polygon.

The modeled scientific community included multiple scientist types, each with a different research strategy, such as performing highly innovative experiments or simple replication experiments. Devezer and her colleagues studied whether factors like the makeup of the community, the complexity of the polygon and the rate of reproducibility influenced how fast the community settled on the true polygon shape as the scientific consensus and the persistence of the true polygon shape as the scientific consensus.

Within the model, the rate of reproducibility did not always correlate with the probability of identifying the truth, how fast the community identified the truth and whether the community stuck with the truth once they identified it. These findings indicate reproducible results are not synonymous with finding the truth, Devezer said.

Compared to other research strategies, highly innovative research tactics resulted in a quicker discovery of the truth. According to the study, a diversity of research strategies protected against ineffective research approaches and optimized desirable aspects of the scientific process.

Variables including the makeup of the community and complexity of the true polygon influenced the speed scientists discovered the truth and persistence of that truth, suggesting the validity of scientific results should not be automatically blamed on questionable research practices or problematic incentives, Devezer said. Both have been pointed to as drivers of the “replication crisis.”


“We found that, within the model, some research strategies that lead to reproducible results could actually slow down the scientific process, meaning reproducibility may not always be the best — or at least the only — indicator of good science,” said Erkan Buzbas , U of I assistant professor in the College of Science , Department of Statistical Science and a co-author on the paper. “Insisting on reproducibility as the only criterion might have undesirable consequences for scientific progress.”

Modeling Chlamydia Infection in Mice

Working Group leader: Lihong Zhao

Group members: Yusuf Omoson (Morehouse School of Medicine), German Enciso (UC Irvine), Ming Tan (UC Irvine), Scott Grieshaber

Originated: April, 2019

Description:

This working group is interested in using mathematical modeling to understand the association of microbial dynamics in the genital tract of female mice with Chlamydia infection. They will analyze sequencing data when it becomes available and plan to submit a manuscript. They would also like funding to continue the project and plan to submit a proposal.

Muc7 Models of Peptide Glycostation (MMPG)

Working Group leader: Kristopher Waynant

Group members: Darren Thompson, Tyler Siegford, Tanner Hahn

Originated: March 1, 2019

Description:

Modeling efforts of Muc7 homologs for understanding possible glycosylation patterning that will allow for bacterial agglutination. Using the preliminary results from this data we are attempting to synthesize the first of these analogs. We hope to see the first expected glycosylation models in September, as to create them synthetically and evaluate their viability.

Geospatial Modeling (GM)

Updated: February 2021

Working Group leader: Erich Seamon

Group members: Bruce Godfrey, Claudio Berti, Paul Gessler, Raymond Dezzani, Jason Karl, Vincent Jansen, Marshall Ma, Luke Sheneman, Naveen Joseph, Alan Kolok, Daniel Cronan, Felix Liao, Jeff Hicke, Chao Fan

Schedule: TBD

Description:

The Geospatial Modeling (GM) Working Group will explore and propose platforms and methodologies for performing spatially-explicit modeling across landscape and watershed scales.  This working group will focus on the interactions of spatial patterns and human and ecological processes as well as enabling heterogeneous data and model interoperability.

Our goal is to build an active community around geospatial modeling in support of current and future IMCI projects, as needed.


Specific areas of interest:

-Climate associations with health

Upcoming related events:

April 2021: University of Idaho Geospatial analysis workshop

Epistasis

Working Group leader: Dan Weinreich

Group members: Tanya Miura, Andreas Vasdekis, Brenda Rubenstein, Craig Miller, David Morgan, Jagdish Patel, JT VanLeuven, Jonathan Barnes, Kyle Martin, Marty Ytreberg, Paul Rowley

Originated: November, 2018

Description:

This working group is interested in empirical and theoretical approaches for understanding epistasis and its evolutionary consequences.