Reproducibility of scientific findings has long been considered a pillar of science. However, in the last decade, many disciplines life sciences have failed to reproduce major research findings. This reproducibility crisis has triggered a shift to revise current research practices. Examples include how to make biomedical findings more reproducible as emphasized in a recent article by NIH directors (Collins and Tabak 2014, Policy: NIH plans to enhance reproducibility, Nature 505, 612–613) and the Cancer Biology Reproducibility Project. Despite these self-correction efforts, little is known about the underpinnings of reproducibility. The goal of this project is to help generate more true research claims than false, by identifying and examining the factors contributing to the non-reproducibility of experimental findings.
New Fish Rack System Helps Advance U of I’s Biomedical ResearchOctober 28, 2019
This article was published by the Office of Research and Economic Development in the October 2019 Scholars and Researchers newsletter. IMCI supports Zebrafish research through modeling via the Evolution of Tandemly-Replicated Opsin Genes: Molecular Models That Predict Spectral Shifts (which led to an article featured on the cover of Science magazine) and Bioinformatic Analysis of […]
Shirley Luckhart awarded Modeling Access GrantJune 18, 2019
Title: DNA and protein modeling for P/asmodium falciparum dhfr and dhps sequences derived from an existing study in Kenya Project Team: Shirley Luckhart, Dharmesh Patel, JT Van Leuven Start Date: June, 2019 The UI, USUHS, and USAMRU-K teams have collected human blood samples from study-enrolled Kenyan adults for an NIH-funded project focused on defining the […]
The Rapid Evolution of Primate Haptoglobin and the Molecular Modeling of its Interaction with the Trypanosome Hemoglobin-Haptoglobin ReceptorMay 6, 2019
Project Team: Paul Rowley, Jagdish Patel, Dharmesh Patel Start Date: May 2019 Molecular dynamics simulations will help Principal Investigators Rowley and Jagdish Patel analyze FoldX. The team expects this research to lead to a publication and serve as the foundation for future grants to investigate haptoglobin evolution in other mammalian species that serve as reservoirs […]