The interaction of host proteins with lentiviruses and other retroviruses and retrotransposons represents a major research theme of the Rowley lab. The proposed work fits well with the mission of the NIH and is a field of study that has traditionally been well supported. Dr. Rowley is fully committed to providing all the necessary support for the development of the molecular models and the production of supporting experimental data. Investigating the complex interactions that occur between the capsid protein of primate lentiviruses (including HIV) and human proteins, to understand the consequences of host evolution on viral replication. Then to identify key determinants of lentivirus-primate interaction, specifically between the Nup153p capsid-interacting motif and the HIV-1 capsid. Use known crystal structures as templates for modeling the polymorphisms present within Nup153 variants.
University of Idaho Receives Grant of Nearly $11M for Biomedical Research ModelingAugust 13, 2020
MOSCOW, Idaho — Aug. 13, 2020 — The University of Idaho has secured a grant of nearly $11 million from the National Institutes of Health to support continued modeling for biomedical research at U of I’s Institute for Modeling Collaboration and Innovation (IMCI). The funding comes as Phase 2 of a Centers of Biomedical Research Excellence (COBRE) grant […]
U of I Researchers, Moscow to Build on COVID-19 Wastewater Testing and AnalysisJuly 21, 2020
This news release, published by central University Communications and Marketing, was written by Alexiss Turner in the College of Engineering. IMCI has research partners and participants in nearly all U of I colleges. MOSCOW, Idaho — July 21, 2020 — Researchers at the University of Idaho have partnered with the City of Moscow to improve wastewater […]
Modeling COVID-19 in IdahoApril 16, 2020
Experts across the nation are using modeling to help make decisions regarding how to respond to COVID-19. But knowing the infection rate in New York or an estimated death toll in Washington state doesn’t really help our great state of Idaho. To address Idaho’s specific rural population, age distribution and travel, modeling researchers at Boise […]