Gene replication is an established mechanism for the generation of raw genetic material upon which evolution may act. For example, tandem replication of genes to generate arrays of paralogs underlies functional diversification in vertebrate sensory systems. Tandem replication of opsin (visual pigment) genes and subsequent neofunctionalization provide selective advantages for the exploitation of novel visual environments, food sources, and mate selection. Despite their importance, the mechanisms underlying the subsequent “acts” of neo-functionalization of new genetic material are not clear. In this Modeling Access Grant proposal, we use the tandemly-replicated cone opsin genes of teleosts and primates to address this significant knowledge gap. The tandemly-replicated cone opsin genes are ideal for this study because many independent tandem replications have occurred very recently, and because experimental protein structures are available to inform molecular models. Early in vertebrate evolution, one-rod opsin (RH1) and four cone opsin.
University of Idaho Receives Grant of Nearly $11M for Biomedical Research ModelingAugust 13, 2020
MOSCOW, Idaho — Aug. 13, 2020 — The University of Idaho has secured a grant of nearly $11 million from the National Institutes of Health to support continued modeling for biomedical research at U of I’s Institute for Modeling Collaboration and Innovation (IMCI). The funding comes as Phase 2 of a Centers of Biomedical Research Excellence (COBRE) grant […]
U of I Researchers, Moscow to Build on COVID-19 Wastewater Testing and AnalysisJuly 21, 2020
This news release, published by central University Communications and Marketing, was written by Alexiss Turner in the College of Engineering. IMCI has research partners and participants in nearly all U of I colleges. MOSCOW, Idaho — July 21, 2020 — Researchers at the University of Idaho have partnered with the City of Moscow to improve wastewater […]
Modeling COVID-19 in IdahoApril 16, 2020
Experts across the nation are using modeling to help make decisions regarding how to respond to COVID-19. But knowing the infection rate in New York or an estimated death toll in Washington state doesn’t really help our great state of Idaho. To address Idaho’s specific rural population, age distribution and travel, modeling researchers at Boise […]