Project 1: Within-Host Dynamics of Co-Infection (CoHo)

Working Group leader: Tanya Miura

Group members: Craig Miller, Ben Ridenhour, JT Van Leuven, Andres Gonzalez, Alex Wixom

Originated: Spring/Summer 2015

Description:

The group began working on establishing a model for viral growth in cell culture and designing experiments to parameterize the model. The group split into 4 separate subprojects (in vitro modeling, microarray analysis, titer estimation, and in vivo modeling). The microarray analysis group (members listed above) are the current ‘CoHo Working Group’, which is working on gene expression analysis from our microarray experiments on co-infected cells and our RNAseq experiment from co-infected mouse lungs.

The titer estimation subgroup (Tanya, Craig, and Jake Ferguson) is not meeting regularly, but has a manuscript in the revision stage. When this manuscript is complete, the project will be finished. The other subgroups are not working on projects at this time.

Publications:

Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory viruses

VanLeuven JT, Ridenhour BJ, Gonzalez AJ, Miller CR, Miura TA (2017) Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory viruses. PLoS ONE 12(6): e0178408.